FastPitch - ready, get set, pitch!

17 11 2008

The ICEHOUSE FASTPitch finals were held on the 12th November at the University of Auckland Business School

Before the competition got underway, Geoff Ross provided some perspective on NZ entrepreneurship. Since his vodka success, Geoff has formed an investment company in conjunction with the other 42 Below founders called the The Business Bakery (baking businesses into bigger businesses). So far the bakery has invested in 3 ventures; The Hyperfactory, Ecoya (A high value candle company) and a outdoor fabric company that uses fibre technology from AgResearch.

NZ is a great place to be an entrepreneur as it is prevalent through our culture. Early farming required fast thinking and resourcefulness. They faced many challenges with solutions based around the No.8 wire mentality. This early entrepreneurship was born out of fight or flight situation. The early farmers had no choice and as a result they poured everything in, leaving no option but to succeed. Geoff believes a similar opportunity is presented to us today with regard to our belittled OECD standings.

Unlike in these earlier periods, there are now a lot of inter/ national business successes that young start-ups can feed from providing faith, knowledge from experiences, drive and motivation. For example 42 Below story. The company sold for 138 million in just 4 years. What if there were 10 ‘42 Belows’ sold off each year ? Consider the income for NZ then. However in order to get to this stage Geoff noted we as NZers need to work on our commitment to our ventures. This was summed up in the quote

‘your first angel investor is yourself’

Other pointers he offered included (taken from his experiences from his recent investor perspective):

  • Procrastination – the perfect business plan does not exist. He would rather see a business than a business plan
  • He vouched for ideas with scale that bypass the traditional means of growing a company through injecting additional human resources.And committed founders that are able to listen to everyone, but also know when to ignore
  • NZers don’t tend to sell ourselves as good as well as we should. Pitches are important and cane lead to your businesses/ ideas being sold within the first sentence. E.g. The Apprentice – ‘ like survivor but in a boardroom with Donald Trump’
  • 42 Below was sold for 7 x revenue when the company was actually losing money. It was only cash flow positive for one month. Our companies should be looking to rapidly build themselves as an asset rather than being concerned with a company dividend.

Onto the competition – 12 finalists with 60secs and 1 powerpoint slide each. From my angle (refer to my scorecard below) the winners were quite clear. They each presented a passionately smooth pitch (most importantly being under time) which clearly defined a great idea. From 75 entries and 3 weeks to prepare the ultimate pitch, I expected a higher quality to come through. It might have been the nerves but I felt many teams did not portray a burning desire to win. Those that did obviously won.

Icehouse Article

Previous press release (has finalists’ descriptions)

Graeme’s Scorecard

Infogrid – 6/10 - Overtime

RAVEBuild – 5/10 - Overtime

uLEARNnCare -6 /10 - Overtime

ClicktheClam – 7.5 /10 – Short and sweet [ Spark 40K Runner-up] - Best Presentation Skills

Wurka - 7/10

Puku – 7/10

Graham – 7/10 – quite a cool concept, good potential

Nikki – 8/10 – clear passion - People’s Choice and Best IP

Optimal Workshop – 8/10 – very smooth - Best Investment Opportunity

ePST - 7/10

BE Intent – 7/10

Pocket Vouchers 8/10 – A concept that works [speaking from experience] - Overall Winner

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An update …

6 11 2008

Around the Blogs

  • Ever wished you could simply forget bad experiences - now you can – My Biotech Life
  • Time to sort those papers – FierceBioResearcher
  • i-phone applications for scientists - BitesizeBio (i-phone applications are a great example of pure innovative genius)
  • Biotech and the Credit Crunch - FierceBiotech

Updates

  • FAST Pitch Competition. After much deliberation about whether I should enter the competition last week, I finally decided against it. It was not the fact that I couldn’t prepare a stunning 60sec pitch J , but whether an early stage proposal (I wouldn’t call it a venture at this stage) would eligible or ‘serious’ enough for the competition. I mean for starters the only prize categories that would be applicable would be ‘Best Presentation Skills’ and ‘Audience Choice’. So I left it for next year when the proposal may be transformed into a venture. Aside from my entering jitters, they have recently announced the finalists for the competition cutting down 75 budding entrepreneurs to 12 finalists who will be pitching on the 12th of November at the UoA Business school. The event has already filled up and should be a great night especially with Geoff Ross as the keynote speaker. It is also great to see the Spark 40K runner up, Click the Clam in the finals.
  • Another ICEHOUSE event happening next week is the KICKSTART Seminar on the 13th Nov. Apparently it’s a full on day consisting of workshops, discussions and seminars from 7.30am till 4pm. It aims at providing early entrepreneurs with a skill set to launch their venture. Fortunately I have been asked to attend (free) through the University.
  • Another important update is that the 2010 Greencard lottery has been open for a month or so now and will close on the 1st December. Apparently approx 260 kiwis are successful each year. So I think I’ll give it a go this year. Its all online this time and as always the hardest thing to do is providing a strict ‘to the book’ photo of yourself - remember don’t bother smiling.
  • Kickstart (different to above mentioned icehouse seminar) & Audacious – After the MBE forum with Peter Fennessy, I went back to the Kickstart/ Audacious website to investigate their mentoring schemes. The program that Peter is involved is the Business Coaching/Mentoring and the ‘ food for thought’ (business version of pdf) services. At UoA, the Spark program also does this through their 40K Challenge where finalists are paired up with mentors to aid them in compiling their business plans (this can also continue post competition). Also through spark there is also a colloquial opportunity whenever there is a need to link up with someone such as a mentor. However there may be an opportunity to set up a formal approach, similar to kickstart, where several ‘gurus of business’ are available for contact outside the challenges for advice/mentoring purposes.

Random

  • According to Doing business project NZ now ranks 2nd as the country with the greatest ease to do business in (out of 181 economies).
  • If in doubt over which party to vote for have a look at the Bill and Ben Party (Check the back of your Party list brochure). The guys from Pulp Sport have teamed up to create their own party. With tertiary students making up 14% of the NZ population, they may get close to that 5% threshold.

thebillandbenpartysmlbillandben

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The R&D Policies: the good, the bad and the lack of

6 11 2008

Well the elections, whether it be NZ or US, seem to be on the tip of everyone’s tongue lately. It’s actually hard to avoid them in your day to day living whether it is TV debates, the latest attack on an MP in the papers or Rodney Hide on the street in his unapproved electoral finance canary yellow jacket.

Being 23yo, I have only had the chance to vote once before and even then I refused to vote due to the lack of a party that provided adequate leadership or wise policies. This time round the prior has remained exactly the same (even with a new National candidate in the picture) with some improvement on the latter. Personally I am swung towards National simply due to a need for a change of government (9 years is long enough Helen). Furthermore the two leading parties which supposedly form the right and left sides of government have become so similar that is hard to go wrong.

Despite my prejudged vote, being in the R&D arena I started surfing through National’s and Labour’s R&D policies. Below I have provided comment / opinion on the various aspects of each party’s policy.

Labour (Click here for policy URL)

FFF – Earlier this year the government introduce the Fast Forward Fund, a $700million fund for investment in food and pastoral sector over the next 10 to 15 years. Labours election policy simply states to retain this fund. Refer to comments about his fund under Nationals policies.

The 15% R&D Tax credit was also introduced this year to help stimulate private sector investment in R&D. Labour is looking to retain this

Vote: RS&T (the entire fund of MoRST approx 650 million, makes up Marsden funds etc) – Labour is looking to make 1/3 non contestable funding in three years.

Labour will in the next 3 budgets increase funding for the Marsden Fund, Health Research, and new Transformational R&D (including new materials) as well as renewable energy research, social research and funding to address the needs of researchers early in their careers (yet they do not specify how much).

The current split in public sector research, science and technology investment is approximately 40 percent basic research, 40 percent strategic research and 20 percent pre-commercial development. This is likely to shift towards basic research to balance the expected increases in private sector investment at the other end of the spectrum. I think the current balance is sufficient, greater than 40 percent of non applied basic research would be too excessive.

National (Click here for policy pdf)

Discontinuing the R&D Tax Credit and Funding More Science

“Discontinue the R&D tax credit and use $315 million of the savings to boost funding for research and science over the next three years. This boost includes $157.5 million for the Performance Based Research Fund, the Marsden Fund, and the Health Research Council, and $157.5 million for secure funding of Crown Research Institutes.” The $315 million is approx a third of the savings from the tax credit (over 3 years). The other savings from it go to the personal tax cut scheme.

This cutting of the R&D tax credit definitely created a stir and bagging from the R&D industry and the taxation industry (no surprises there, as less tax regulations = less business for them). Check out the below links for the reactions to Nationals decision.

ARTICLE 1, ARTICLE 2, ARTICLE 3

Apart from the ugly results delivered in the PREFU (resulting in the complete cutting of the credit from the reduced 10% rate) they cite some interesting reasons for cutting the tax credit.

The objective of the tax credit was to increase investment in R& D. However they believe that the credit would simply be subsidising R & D that would have happened anyway. While this justification is true, it still misses a point. The credit frees up additional money to allow R&D projects to be undertaken that previously that weren’t financially feasible.

It is also not clear how much additional R&D this will encourage. Specifically the means of how to measure this increase/decrease ? How would they distinguish from companies simply claiming more expenses under R&D expenditure?

A good result of the cut is that it also frees up some cash for injection into a CRI dedicated fund and other basic research funds.

Ultimately does this mean there is a net loss of approx $700 million over three years that would otherwise be savings from R&D expenditure due to the presence of the tax credit? When I put it like that I does definitely sound like R&D is missing out on A LOT.

Secure Funding for CRIs

Set up a new secure funding allocation for Crown Research Institutes, made up initially from: Savings from discontinuing the R&D tax credit and the funding currently in the CRI Capability Fund. This may also free up funding sources previous hunted by CRI researchers.

Boosting Primary Sector Research

Wind up the Fast Forward Fund. My personal opinion on this fund is that its very focus on food and pastoral science is its downfall. Of course being in the human therapeutics area I’m most likely biased, but I believe despite our strong history in agriculture, other areas of science research (biomedical for example) deserve equal attention. Especially considering how well of human health biotech companies have been doing (Neuren, LCT, Protemix, Coda to name a few).

On first look you may think that all of AgBio comes under the FFF, however it does miss out a lot of important and economically significant fields/sectors such as wood, wool and hides.

Being a separate fund it also requires own management structure i.e. wasted money. National’s solution uses existing infrastructure to deliver the funds.

Instead the money will be directed into three areas.

  1. Establish an international centre for research dedicated to the reduction of on-farm greenhouse gas emissions, and fund it at $20 million a year. – Not my favourite course of action as there are already groups researching this e.g. vaccination of cows to cut down methane producing bacteria in the rumen. Simply funding the projects already in place such as 5 mill over 5 years.
  2. Boost funding within Vote RS&T for primary sector and food research by $25 million a year. National actually states the funding increases to be made.
  3. Boost funding for research consortia in the primary and food sectors by $25 million a year. Note compared to the FFF this funding scheme contains a broader Agritech/bio focus. Rather than a 10-15 year 700 million commitment , they are only committed to a $210 million over three years

Prime Minister’s Prize for Science

Introduce annual Prime Minister’s Prizes for Science, and make $1 million a year available to fund them. I don’t think this is necessary is there are other National science prize schemes already in place e.g. MacDiarmid Young Scientist of the Year

Science at the Heart of Government

Create a new role of Prime Minister’s Science Adviser. This role will be filled by a scientist seconded for a time from the sector. I thought this was already in place as Nick Bain previously filled this/ or similar position.

Reducing Compliance Costs

Reduce compliance costs and unnecessary bureaucracy within the science system. Great point! To bad they can’t extend the reduction of bureaucracy and over-management  through to other departments.

Overall it seems like National is severely cutting R&D investment and investing a portion of the savings back into R&D through other channels to soften the blow. With such it makes me wonder where Labour is actually getting the money for their income tax cuts. However it looks like National has put a lot more thinking gone into National’s policies. However both proposals, as expected, are far from perfect. For example one area of concern, not addressed by either party is the funding structure and operation. Too much time is spent writing unsuccessful grant applications. This is time which could have been spent increasing R&D expenditure. There needs to be a consolidation somewhere along the line.

Other side mentioned intentions of National include the rewarding of IP inventors in CRIs and increased student co-supervision in CRIs, which is already happening especially with HortResearch





Chiasma Career Catalyst Session 3

27 10 2008

Commercialisation - Turning Science into a Business

Speaker: Adam Podmore, UniServices Business Manager in Biotech/ Pharma

Adam provided a view of science commercialisation using the ‘UniServices’ approach as an example. While I had come across most of the content before in other commercialisation/ funding workshops, I found their process for analysing new inventions/ideas quiet insightful. This matched with the activity provided students with a great introduction into the world science research commercialisation.

Facts about UniServices

  • conduct contract research on behalf of external parties  while also commercialising the IP generated within the University
  • Predicted to generate $140 million in 2012
  • Have spun out 23 companies, approx 7 being in the biotech area. They are aiming to achieve 3-4 more a year.
  • Employ a stage gate model (refer to figure below)
  • Inventors take 33% of the benefits extracted from the IP. For students, the reliance is on their supervisor to see their IP interests are managed and accounted for.
  • UniServices have created a seed fund based on superannuation funds from Australia in order to get companies across the ‘valley of death’.
  • Funding is given for proof of concept studies $5-15K, Stage 2: 10-100K allowing prototype development/ in vivo data to get get ready for the industry. This is followed by seed funding and development of a full business plan resulting in the spinning out of a company of licensing of the technology.

Figure: The Stage Gate Model to Commercialisation for UniServices Ref: UniServices Intranet

Analysing ideas- To analyse whether to invest in research of a commercial nature, UniServices employs 5 areas of criteria to score a proposal.

  • Business strategy - does it fit the business profile
  • Technical success - resources required, manufacturing capacity and skills capability
  • Does it have commercial success - its market, competitors, uniqueness
  • Reward - investment required? What will be the return? How long will a return take?
  • The X FACTOR

Funding avenues for biotech

  • basic research grants
  • spin out a company and raise investment or license - is the the company based on a platform technology? More likely to spin out rather than license if the IP is a platform technology with multiple applications.
  • Seed funding - typically earlier than VCs ranging from 100k- 1mill
  • VC - Series A 10mill (can be instead of seed), Series B 30mill (typically for phase 2, trying to achieve a 5x return)
  • IPO - a hard road to take
  • Trade Sale - favoured exit strategy

Example: Proacta - the makers of PR-104, a small molecule prodrug targeting hypoxic tumours.

‘04 - 8million Series A funding from GBS Ventures, Genetech/Roche, No.8 Ventures/ Endeavour Capital

‘07 - 35million in Series B funding from Claris and Delphi Ventures

ACTIVITY:

Assess whether we (controllers of a seed fund) would invest (1.5 million) in a new small molecule anti-cancer compound, SN28049 . A profile of this technology can be found at: http://www.uniservices.co.nz/pageloader.aspx?page=1487d8d0d82

Based on point scoring scale using the criteria under ‘analysing ideas’ our decision was - ‘Yes, grant funding but in the form of milestone payments’. The team has a strong proven ability to commercialise successful chemotherapeutics. The drug itself exhibits a strong profile in both toxicology and efficacy data with clear benefits over competing drugs.






Careers in the Life Sciences

22 10 2008

I found a great diagram that explains the diversity in careers that one can have in the life science (and wider biotech) industry. The circled branches typically resemble the limitations of students’ career perceptions. Hopefully with Chiasma around this is broadening.

Taken from ‘Career Opportunities in Biotechnology and Drug Development’ by Toby Freedman





www.madefromnewzealand.com

21 10 2008

A new site focused on linking together the complementary talent, skills, experiences and knowledge of NZ entrepreneurs to help new local businesses to start-up.

Herald article





MBE Forum: Peter Fennessy - AbacusBio

21 10 2008

“Start-ups: intuition and insouciance or the 10 things I wish I had known 20 years ago”

The last Bioscience Enterprise forum for the year featured AbacusBio founder and Managing Director Peter Fennessy. Peter has an extensive R&D background including a PhD in Biochemistry and Nutrition and 5 years applied research with AgResearch. He is also a Board member of Blis Technologies, NZBIO and the NRCGD. AbacusBio is a new venture consulting business that bridges AgBio science and business.

Throughout Peter’s presentation he focused on 4 areas of advice for a business start-up:

1:Things he would have love to have known 20 years ago (both as himself and as an investor)

  • Attitude – have to keep it fun, grounded, regular reality checks with an outside interest.
  • Mentor – Peter stressed the usefulness of a mentor but be clear what you want from them. In a later side note, Prof. Wendell Dunn (Foundation Chair in Entrepreneurship, UoA) stated that there were 3 types of mentor:mentoree interactions: 1- personal (focused on the development of the person) 2- the confidant 3- technical/ focused on the business. Peter, despite being a mentoree himself, he too is a mentor for students at the University of Otago that are looking to start their own businesses. I believe this is under the KickStart Program.
  • Realise your weaknesses
  • What are you trying to do? Are you creating a business or buying a job. The motivation needs to be there.

2:‘Doing It’

  • If your project has a strong need associated with it get it in the market ASAP as early adopters will test and give you valuable feedback to continue to develop your product.
  • Kill it quickly. Find out what will kill your product. Because of his links with Blis Tech he made reference to Probiotics. Stability is the Achilles heel of a probiotic product (good news for Encoate).
  • Be Flexible – The business you thought you were in might not be your actual business. Your business concept may be premature- let it evolve.

3:Ideas

  • Expose yourself to them – read read read
  • Don’t be too precious about your ideas – to test it you need to share it. Peter mentioned it’s not so much the idea but how you put it into practice that counts, providing the PCR technology as an example.
  • ‘Ideas are easier than actually following them through’
  • Recommended 2 authors – Jim Collins ( and Clayton Christensen (The Innovators Dilemma)

4: The Business Concept

  • It is always harder to sell a product than what you think
  • The technology is important but not everything
  • What is your point of difference in the market?
  • What is the IP situation around your innovation?

Blis Tech produced the first oral probiotic in the world. Other probiotics are typically found in dairy products for consumption. It was a throat spray that prevented strep throat infections having particular benefit on board long flights. Nestle have recently signed off on a deal with Blis for use of their product in an infant formula and has significantly boosted the creditability of the company and its hopes of profitability.





Job cuts at AgResearch - Am I missing something ?

15 10 2008

Last week AgResearch announced plans to cut jobs to the tune of $5 million worth [Herald article]. Their reasoning being, in order to return a “more satisfactory profit”. Building on my MBE Forum- NIWA post, apparently CRIs are expected to turn a profit, I should hope so, a small one at that.

However CRIs along with our Universities act as the primary developing grounds for our emerging scientists and knowledge centers where research heavily aligned with this country’s core competencies is built upon (i.e the AgBio field). Job cutting at these institutions simply begins to strip NZ’s talent pools and knowledge tanks, sending scientist offshore and halting the research they once directed.

What kind of job security do scientists have in this country if a position at a government funded institution is not stable ? Retaining and developing talented staff should be paramount to their profit driven objectives. Don’t get me wrong, I strongly believe CRIs should be acting more like corporates in terms of fulfilling their commercial potential. My quarrel lays with in how they execute this, there are better ways than taking what seems a lazy approach to keep JUST out of the red. Say….. see where you can offer more services or contract research or begin to reel in the value from your IP banks. 35 available licensing opportunities x 150K each - there’s your 5 million (plus a little for a ‘healthy’ surplus). I know its not that simple, but I’m sure it can’t be that hard either.

PS: My frustration begins dissipates as I find they do have their own pre-seed fund.

Update 4/11/08 - Maybe they took my advice :) - LINK





Win a $5000 website with Domainz

15 10 2008

DOMAINZ has a competition running until Dec 5th for NZ registered companies. The winner receives a professionally built website worth $5000. To enter contestants have to pitch their business idea in 25 words or less. As the term and conditions state, ‘ the most creative entry will win the prize’. Check it out, getting paid $200 a word sounds like a good deal to me.

LINK





Start-up.co.nz - Bookmark it !

13 10 2008

I have come across www.start-up.co.nz several times in my nightly web surfing rituals. I must say its a site all upcoming web entrepreneurs should be adding to their bookmarks. The website is an online resource for online start-ups featuring articles and videos focused on delivering advice about aspects of business start-up. The website also includes blogs and the an online community portal. In the blog section Ben Milsom, co-founder of Nexx (Spark 40K winner 2007), provides some great commentary about the journey of developing an online start-up. Like that of Idealog and Unlimited, ‘the website’ is part of the whole package that is required for modern publications to succeed - an offline AND online presence. The magazine was launched in Dec ‘07 and is now in its second issue. Idealog has had some great success creating its Idealog TV resource, a collection short online videos based around interviews with influential people such as Geoff Ross (42 Below), David Skilling (NZ Institute) and Ray Avery ( Medcine Mondiale). Start-up has taken this one step further by creating a TV series for TVNZ (currently in production), Startup TV. The TV show follows the lives of NZ IT entrepreneurs as they seek to create successful businesses mixed in with a Dragons Den-like competition. The prize ? They get to launch their product at a Tech conference/meeting in Silicon Valley [Herald article]. Keep any eye out for it …